GROWTH ACTIVITY TEST OF WHITE RAT HAIR COMBINATION OF CELERY (Apium Graveolens) LEAF EXTRACT AND GREEN GEDI (Abelmoschus Manihot) LEAF

Chelsea Kawatu; Julianri Sari  Lebang; Meilani  Jayanti

doi:10.53682/ibj.v5i3.11058

Authors

Chelsea Kawatu Universitas Sam Ratulangi
Julianri Sari Lebang Universitas Sam Ratulangi
Meilani Jayanti Universitas Sam Ratulangi

DOI:

https://doi.org/10.53682/ibj.v5i3.11058

Abstract

Celery and Green Gedi leaves have been long considered traditional topical supplements to support hair growth. They contain flavanoids that are efficacious to induce keratinocyte proliferation. However, the research about whether the combination of celery and green gedi leaves can still provide an effect is limited. This current study aims to determine the effect of the combination of ethanol extracts of celery leaves and green gedi leaves on white rat hair growth. This is laboratory experimental research to compare the hair growth in three different groups with normal and positive control. Animals were randomly grouped (n=3 for each group) and then given a combination of leaf extracts and carbopol with a concentration of 17.5%:10%; 27.5%:15%;37.5%:20%. A normal control group was left untreated, while another group was treated with 2% minoxidil as positive control. The results of measuring fur weight on day 21 showed that the treatment group given the combination of extracts did affect the growth of rat hair. Statistical tests using one-way ANOVA showed a p-value of <0.001 which means there is a significant difference in the average hair weight of rats treated. LSD post hoc test showed that treatment with a 17.5%:10% concentration ratio was significantly different from the other treatments. It can be concluded that the combination of celery leaf extract and gedi leaf positively affects rat hair growth.

References

Anuar, A. H. B. S., & Levita, J. (2018). Review: Seledri Apium Graveolens. Linn. Sebagai Tablet Anti-Inflamasi. Jurnal Farmaka, 16(1), 72–82.

Ayuningtyas, D. & Linawati, M. (2018). Peranan Follicular Unit Grafting Dalam Mengatasi Alopeca. Jurnal Media Udayana, 2(8): 1365-1377

Sari, D. K., & Wibowo, A. (2016). Perawatan herbal pada rambut rontok. Medical Journal of Lampung University [MAJORITY], 5(5), 129-134.

Pratiwi, E. N. A., Putra, I. G. N. A. D., & Setyawan, E. I. (2022). Aktivitas analgesik tanaman gedi (Abelmoschus manihot L.) pada mencit (Mus musculus). Humantech: Jurnal Ilmiah Multidisiplin Indonesia, 2(3), 477-484.

Hendrika, G., Rahayu, A., & Mulyaningsih, Y. (2017). Pertumbuhan Tanaman Seledri (Apium graveolens L.) Pada Berbagai Komposisi Pupuk Organik Dan Sintetik. Agroninda, 3((1)), 01–09.

Hindun, S., Akmal, A., Najihudin, A., Sari, N. (2017). Formulation of Hair Tonic Combination of Celery and Green Tea Leaves Ethanol Extract for Rabbit Hair Growth. Jurnal Ilmiah Farmako Bahari, 8, 21–33.

Amalia, A. R., Nurrahman, A., Sari, D. W., & Firdaus, M. (2024). Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus. Eureka Herba Indonesia, 5(3), 470-480.

Ngelu, F. Y., Marbun, F. D., Sihombing, A. M., Manalu, Y., Ate, V. R. K. M., & Riswanto, F. D. O. (2022). Potensi Ekstrak Seledri (Apium graveolens L) Sebagai Antibakteri. Jurnal Jamu Kusuma, 2(1), 23-29. https:// doi.org/10.37341/jurnaljamukusuma.v2i1.22

Nurdianti, L., Azzahra, S. F., & Aji, N. (2017). Pengembangan formulasi sediaan gel rambut antiketombe ekstrak daun pandan wangi (Pandanus amaryllifolius Roxb.) dengan menggunakan viscolam sebagai gelling agent dan uji aktivitasnya terhadap jamur Pityrosporum ovale. Jurnal Kesehatan Bakti Tunas Husada, 17(2), 456-467

Nurjanah, & Krisnawati, M. (2014). Pengaruh Hair Tonic Lidah Mertua (Sanseviera Trifasciata Prain) dan Seledri (Apium Graveolens Linn) Untuk Mengurangi Rambut Rontok. Journal of Beauty and Beauty Health Education, 3(1), 1–7.

Orin Tri Wulan, Raden B. (2018). Profil Fitokimia dan Aktivitas Farmakologi Gedi (Abelmoschus manihot (L.) Medik.). Suplemen Volume 16 Nomor 2.

Dalimarta, S. ( 2016). Atlas Tumbuhan Obat Indonesia (Vol.2). Jakarta: PT. Trubus Agriwidya

Rori, W. M. (2016). Formulasi dan evaluasi sediaan tablet ekstrak daun gedi hijau (Abelmoschus manihot) dengan metode granulasi basah. PHARMACON, 5(2).

Runtuwene, P. M., Winaya, K. K., & Dewi, N. N. A. (2023). Topical Administration of Red Gedi Leaves (Abelmoschus Manihot L. Medik) Gel Extract Increases Neovascularization, Number of Fibroblasts and Re-Epithelialization on Wounds in Diabetic Rats. International Journal of Scientific and Creative Innovations, 4(6), 998–1007.

Taroreh, M., Rahardjo, S., Hastuti, P., & Murdiati, A. (2015). Ekstraksi daun gedi (Abelmoschus Manihot L) secara sekuensial dan aktivitas antioksidannya. Agritech, 35(3), 280-287.