Anticancer Activity Of Apis Dorsata Binghami Nest Extract From West Uluway Tana Toraja District

Abstract

Cancer is the leading cause of death in the world with a high prevalence in Indonesia especially breast cancer Conventional therapies such as chemotherapy and radiotherapy have various limitations including severe side effects and cancer cell resistance This study aims to explore the anticancer potential of the ethanol extract of Apis dorsata < em>Binghami nests originating from Uluway Barat Village Tana Toraja Regency Extraction was carried out using the maceration method with 96 ethanol solvent with a yield of 51 42 and bioactive compounds were identified through GC MS analysis Anticancer activity tests were carried out in vitro < em>on MCF 7 breast cancer cells using the resazurin assay method < em> The results showed that the extract contained various bioactive compounds such as flavonoids furanones and aromatic aldehydes which are known to have antioxidant and anticancer activities The IC50 value _{obtained < sub>was 434 30 g mL indicating weak cytotoxic activity Nevertheless this extract showed significant ability to kill cancer cells at certain concentrations especially 15 63 g mL which reduced cell viability by 44 39 These results indicate that A dorsata < em>Binghami nests contain compounds that have the potential as natural anticancer agents but require further research for fractionation and identification of more specific active compounds and further testing in vivo < em>< p>}